The Chemical and Functional Genomics Lab has established an integrated screening platform with advanced laboratory automation technology for cell-based and whole organism (e.g. microbial, worm and zebrafish) assays that is managed in collaboration with the NYUAD CTP.
The High-Throughput Screening Platform allows researchers to rapidly automate chemical and biological processes. This platform is optimized to carry out most of the steps involved in high-throughput screening of small molecule or genomic (e.g., RNAi, CRISPR) libraries. These steps include mixing reagents with cells or whole organisms, sample incubation in controlled environments, and high-content imaging at multiple levels of magnification in both bright-field and multi-channel fluorescence modes.
The HTP is capable of performing a variety of processes such as liquid handling, imaging, incubation, labeling, shaking, sealing and can be adaptable to any new process required by adding a new equipment and integrating it with the rest of the automated system.
The users of this platform are currently focusing on screening large libraries of chemical and biological reagents for bioactive compound discovery, toxicity studies, and cell biology research.