The liver accomplishes an amazing array of physiological tasks, including energy homeostasis, xenobiotic metabolism, serum protein secretion and bile production. Despite the remarkable regenerative capacity of the liver, it is not always able to undergo efficient repair. Thus, diseases of the liver are common. Our lab uses zebrafish to understand liver development and disease.
Current projects focus on two topics:
The liver accomplishes an amazing array of physiological tasks, including energy homeostasis, xenobiotic metabolism, serum protein secretion and bile production. Despite the remarkable regenerative capacity of the liver, it is not always able to undergo efficient repair. Thus, diseases of the liver are common and a long-term goal of our research is to identify targets to treat them. We use zebrafish as a model system to accomplish these goals.
Decoding the contribution of DNA methylation to hepatocyte proliferation during liver development and in the regulation of liver cancer
Metabolic Disease
Understanding the relationship between stress in the secretory pathway, the unfolded protein response, and fatty liver.
