Publications

Macchi, Filippo, Eric Edsinger, and Kirsten C. Sadler. "Epigenetic machinery is functionally conserved in cephalopods." BMC biology 20, no. 1 (2022): 1-23.

Nair, Anjana Ramdas, Priyanka Lakhiani, Chi Zhang, Filippo Macchi, and Kirsten C. Sadler. "A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver." Genomics 114, no. 1 (2022): 107-124.

Zhang, Chi, Filippo Macchi, Elena Magnani, and Kirsten C. Sadler. "Chromatin states shaped by an epigenetic code confer regenerative potential to the mouse liver." Nature communications 12, no. 1 (2021): 4110.

Magnani, Elena, Filippo Macchi, Bhavani P. Madakashira, Chi Zhang, Fatima Alaydaroos, and Kirsten C. Sadler. "uhrf1 and dnmt1 loss induces an immune response in zebrafish livers due to viral mimicry by transposable elements." Frontiers in immunology 12 (2021): 627926.

Wang, Shuang, Chi Zhang, Dan Hasson, Anal Desai, Sucharita SenBanerjee, Elena Magnani, Chinweike Ukomadu, Amaia Lujambio, Emily Bernstein, and Kirsten C. Sadler. "Epigenetic compensation promotes liver regeneration." Developmental cell 50, no. 1 (2019): 43-56.

Bambino, Kathryn, Chi Zhang, Christine Austin, Chitra Amarasiriwardena, Manish Arora, Jaime Chu, and Kirsten C. Sadler. "Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish." Disease models & mechanisms 11, no. 2 (2018): dmm031575.

Chernyavskaya, Yelena, Raksha Mudbhary, Chi Zhang, Debra Tokarz, Vinitha Jacob, Smita Gopinath, Xiaochen Sun, Sadler, K.C., et al. "Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling." Development 144, no. 16 (2017): 2925-2939.

DeRossi, Charles, Ana Vacaru, Ruhina Rafiq, Ayca Cinaroglu, Dru Imrie, Shikha Nayar, Anastasia Baryshnikova, Sadler, K.C.,  et al. "trappc11 is required for protein glycosylation in zebrafish and humans." Molecular biology of the cell 27, no. 8 (2016): 1220-1234.

Jacob V, Chernyavskaya Y, Chen X, Tan PS, Kent B, Hoshida Y, Sadler KC. 2015. DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Development. Feb 1;142:510-521. Epub 2015/01/08.

Mudbhary, R., Hoshida, Y., Chernyavskaya, Y., Jacob, V., Villanueva, A., Fiel, M.I., Chen, X., Kojima, K., Thung, S., Bronson, R.T., Lachenmayer, A., Revill, K., Alsinet, C., Sachidanandam, R., Desai, A., SenBanerjee, S., Ukomadu, C., Llovet, J.M., Sadler, K.C.,. "UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma." Cancer cell 25, no. 2 (2014): 196-209.

Howarth DL, Lindtner C, Vacaru AM, Sachidanandam R, Tsedensodnom O, Vasilkova T, Buettner C, Sadler KC. 2014. Activating transcription factor 6 is necessary and sufficient for alcoholic Fatty liver disease in zebrafish. PLoS Genet. May;10:e1004335. Epub 2014/05/31.

Vacaru AM, Di Narzo AF, Howarth DL, Tsedensodnom O, Imrie D, Cinaroglu A, Amin S, Hao K, Sadler KC. 2014. Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish. Dis Model Mech. Jul;7:823-835. Epub 2014/06/29.

Tsedensodnom O, Vacaru AM, Howarth DL, Yin C, Sadler KC. 2013. Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in alcoholic liver disease. Dis Model Mech. Jun 27; 6:1213-1226. Epub 2013/06/27.

Chu J, Loughlin EA, Gaur NA, Senbanerjee S, Jacob V, Monson C, Kent B, Oranu A, Ding Y, Ukomadu C, et al. 2012. UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis. Mol Biol Cell. Jan;23:59-70. Epub 2011/11/11.

Sadler, Kirsten C. "The shifting culture of the scientific workforce–a change for women and girls in science." Disease models & mechanisms 16, no. 2 (2023): dmm050111.

Sadler, Kirsten C. "Epigenetics across the evolutionary tree: New paradigms from non‐model animals." BioEssays 45, no. 1 (2023): 2200036.

Hahn, Mark E., and Kirsten C. Sadler. "Casting a wide net: use of diverse model organisms to advance toxicology." Disease models & mechanisms 13, no. 4 (2020): dmm043844.

Macchi, Filippo, and Kirsten C. Sadler. "Unraveling the epigenetic basis of liver development, regeneration and disease." Trends in Genetics 36, no. 8 (2020): 587-597.

Monga, Satdarshan P., and Kirsten C. Sadler. "An epigenetic perspective on liver regeneration." Epigenomics 12, no. 5 (2020): 381-384.

Madakashira BP, Sadler KC. 2017. DNA Methylation, Nuclear Organization, and Cancer. Front Genet.8:76. Epub 2017/06/24.

Goessling W, Sadler KC. 2015. Zebrafish: An Important Tool for Liver Disease Research. Gastroenterology. Nov;149:1361-1377.

Vacaru AM, Unlu G, Spitzner M, Mione M, Knapik EW, Sadler KC. 2014. In vivo cell biology in zebrafish - providing insights into vertebrate development and disease. J Cell Sci. Feb 1;127:485-495. Epub 2014/02/01.

Imrie D, Sadler KC. 2012. Stress Management: How the Unfolded Protein Response Impacts Fatty Liver Disease. J Hepatol. Jun 22;57 1147-1151. Epub 2012/06/27.

Chernyavskaya Y, Kent B, Sadler KC. 2016. Zebrafish Discoveries in Cancer Epigenetics In: Cancer and Zebrafish. Springer. p. 169-197.

Wang S, Miller SR, Ober EA, Sadler KC. 2017. Making It New Again: Insight Into Liver Development, Regeneration, and Disease From Zebrafish Research. Curr Top Dev Biol.124:161-195.