Publications

All Publications

• 2024 Publications

  Khan N, Salmi TM, Karamalakis AP, Nair AR, Sadler KC, Cox AG. Optimised methods to image hepatic lipid droplets in zebrafish larvae. Disease Models and Mechanisms. 2024. (in press)

  Koomson, A.A., Delaney, P., Khan, N. and Sadler, K.C. ( 2024). Sustained effects of developmental exposure to inorganic arsenic on hepatic gsto2 expression and mating success in zebrafish. Biology Open. 13(3), p.bio060094. PMID: 38446164

  Madakashira, B.P., Magnani, E., Ranjan, S. and Sadler, K.C. (2024). DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic Acids Research. 52(6), pp.3069-3087. PMID: 38321933

  Magnani E, Nair AR, McBain I, Delaney P, Chu J, Sadler KC. (2024). Methods to Study Liver Disease Using Zebrafish Larvae. Methods in Molecular Biology 2707:43-69. PMID: 37668904.

• 2023 Publications

  Sadler KC. (2023). The shifting culture of the scientific workforce - a change for women and girls in science. Disease Models & Mechanisms.16(2):dmm050111. PMID: 36752155

  Ajouaou Y, Magnani E, Madakashira B, Jenkins E, Sadler KC. (2023) atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers. Cancers. 15(8):2302. PMID: 37190230

  Sadler KC. (2023). Epigenetics across the evolutionary tree: New paradigms from non-model animals. Bioessays. 45(1):e2200036. PMID: 36403219

• 2022 Publications

  Ramdas Nair, A., Lakhiani, P., Zhang, C., Macchi, F., & Sadler, K. C. (2022) A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver. Genomics. 114(1), 107–124. PMID: 34863900
  

  Macchi, F., Edsinger, E., Sadler, K.C. (2022) Epigenetic machinery is functionally conserved in cephalopods. BMC biology. 20, no. 1: 1-23. PMID: 36104784

• 2021 Publications

  Ramdas Nair, A., Delaney, P., Koomson, A.A., Ranjan, S., and Sadler, K.C. (2021) Systematic Evaluation of the Effects of Toxicant Exposure on Survival in Zebrafish Embryos and Larvae. Current Protocols. 1(9):e231. PMID: 34491623

  Madakashira, B.P.,  Zhang, C.,  Macchi, F.,  Magnani, E., and Sadler, K.C. (2021) Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1. Genes. 12(7):1081. PMID: 34356097

  Zhang, C., Macchi, F., Magnani, E., and Sadler, K.C. (2021) Chromatin states shaped by an epigenetic code confer regenerative potential to the mouse liver. Nature Communications. 12(1):4110. PMID: 34226551

  Wang, S., Ruiz de Galarreta, M., Sadler, K. C., & Lujambio, A. (2021). Manipulating and tracking single hepatocyte behavior during mouse liver regeneration by performing hydrodynamic tail vein injection. STAR protocols, 2(2), 100440. https://doi.org/10.1016/j.xpro.2021.100440. PMID: 33899021

  Magnani, E., Macchi, F., Madakashira, B., Alydaroos, F., Zhang, C., and Sadler, K.C. (2021) uhrf1 and dnmt1 loss induces an immune response in zebrafish livers due to viral mimicry of transposable elements. Frontiers in Immunology. 12:627926. PMID: 33854502

• 2020 Publications

  Delaney, P., Nair, A.R., Palmer, C., Khan, N., and Sadler, K.C. (2020) Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish. Toxicol Appl Pharmacol. 115307. PMID: 33147493.

  Macchi, F. and Sadler, K.C. (2020) Unraveling the Epigenetic Basis of Liver Development, Regeneration and Disease. Trends Genet. 36(8): 587-597. PMID: 32487496.

  Sharma, S. K., Al Hosani, S., Kalmouni, M., Nair, A. R., Palanikumar, L., Pasricha, R., Sadler, K. C., Magzoub, M., & Jagannathan, R. (2020). Supercritical CO2 Processing Generates Aqueous Cisplatin Solutions with Enhanced Cancer Specificity. ACS omega, 5(9), 4558–4567. https://doi.org/10.1021/acsomega.9b03917. PMID: 32175502

  Monga, S. P., & Sadler, K. C. (2020). An epigenetic perspective on liver regeneration. Epigenomics, 12(5), 381–384. https://doi.org/10.2217/epi-2020-0010. PMID: 32090611

  Hahn, M. E., & Sadler, K. C. (2020). Casting a wide net: use of diverse model organisms to advance toxicology. Disease models & mechanisms, 13(4), dmm043844. https://doi.org/10.1242/dmm.043844. PMID: 32094287

  Benyettou, F., Ramdas Nair, A., Dho, Y., Prakasam, T., Pasricha, R., Whelan, J., Traboulsi, H., Mazher, J., Sadler, K. C., & Trabolsi, A. (2020). Aqueous Synthesis of Triphenylphosphine-Modified Gold Nanoparticles for Synergistic In Vitro and In Vivo Photothermal Chemotherapy. Chemistry (Weinheim an der Bergstrasse, Germany), 26(23), 5270–5279. https://doi.org/10.1002/chem.202000216. PMID: 32077541

  Benyettou, F., Das, G., Nair, A. R., Prakasam, T., Shinde, D. B., Sharma, S. K., Whelan, J., Lalatonne, Y., Traboulsi, H., Pasricha, R., Abdullah, O., Jagannathan, R., Lai, Z., Motte, L., Gándara, F., Sadler, K. C., & Trabolsi, A. (2020). Covalent Organic Framework Embedded with Magnetic Nanoparticles for MRI and Chemo-Thermotherapy. Journal of the American Chemical Society, 142(44), 18782–18794. https://doi.org/10.1021/jacs.0c05381. PMID: 33090806

• 2019 Publications

  • Journals

    Benyettou, F., Prakasam, T., Ramdas Nair, A., Witzel, I. I., Alhashimi, M., Skorjanc, T., Olsen, J. C., Sadler, K. C., & Trabolsi, A. (2019). Potent and selective in vitro and in vivoantiproliferative effects of metal-organic trefoil knots. Chemical science, 10(23), 5884–5892. https://doi.org/10.1039/c9sc01218d. PMID: 31360392

    Wang, S., Zhang, C., Hasson, D., Desai, A., SenBanerjee, S., Magnani, E., Ukomadu, C., Lujambio, A., Bernstein, E., and Sadler, K.C. (2019) Epigenetic Compensation Promotes Liver Regeneration. Dev Cell. 50(1): 43-56 e6. PMID: 31231040.

  • Edited Books

    Shuang Wang., Sophie R. Miller., Elke A. Ober., Kirsten C. Sadler. Making it new again: Insight into liver development, regeneration, and disease from zebrafish research. Book Chapter in Current Topics in Developmental Biology: Zebrafish at the Interface of Development and Disease Research. Academic Press. Elsevier. PP: 161-178. The book was edited by Dr. Kirsten Sadler Edepli. 
    

• 2018 Publications

  Bambino, K., Zhang, C., Austin, C., Amarasiriwardena, C., Arora, M., Chu, J., & Sadler, K. C. (2018). Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish. Disease models & mechanisms, 11(2), dmm031575. PMID: 29361514

  Nudelman, G., Frasca, A., Kent, B., Sadler, K. C., Sealfon, S. C., Walsh, M. J., & Zaslavsky, E. (2018). High resolution annotation of zebrafish transcriptome using long-read sequencing. Genome research, 28(9), 1415–1425. https://doi.org/10.1101/gr.223586.117. PMID: 30061115

• 2017 Publications

  Madakashira, B., Corbett, L., Zhang, C., Paoli, P., Casement, J. W., Mann, J., Sadler, K. C., & Mann, D. A. (2017). Variant Histone H2afv reprograms DNA methylation during early zebrafish development. Epigenetics. 2017 Sep;12(9):811-824. Epub 2017 Nov 24. PMID: 29099280

  Chernyavskaya, Y., Mudbhary, R., Zhang, C., Tokarz, D., Jacob, V., Gopinath, S., Sun, X., Wang, S., Magnani, E., Madakashira, B. P., Yoder, J. A., Hoshida, Y., & Sadler, K. C. (2017). Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Development 2017: Aug 15;144(16):2925-2939. PMID: 28698226

  Madakashira, B. P., & Sadler, K. C. (2017). DNA Methylation, Nuclear Organization, and Cancer. Frontiers in genetics, 8, 76. https://doi.org/10.3389/fgene.2017.00076. PMID: 28638402

  Shtraizent, N., DeRossi, C., Nayar, S., Sachidanandam, R., Katz, L. S., Prince, A., Koh, A. P., Vincek, A., Hadas, Y., Hoshida, Y., Scott, D. K., Eliyahu, E., Freeze, H. H., Sadler, K. C., & Chu, J. (2017). MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect. eLife, 6, e22477. https://doi.org/10.7554/eLife.22477. PMID: 28644127

• 2016 Publications

  Chi Zhang, Yujin Hoshida and Kirsten C. Sadler, Comparative epigenomic profiling of the DNA methylome in mouse and zebrafish uncovers high interspecies divergence. Front. Genet., 17 June 2016
  

  DeRossi C, Vacaru A, Rafiq R, Cinaroglu A, Imrie D, et al. trappc11 is required for protein glycosylation in zebrafish and humans. Mol Biol Cell. 2016 Feb 24; PubMed PMID: 26912795.
  

  Kent B, Magnani E, Walsh MJ, Sadler KC. UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development. Dev Biol. 2016 Feb 3; PubMed PMID: 26851214.
  

• 2015 Publications

  Goessling W, Sadler KC. Zebrafish: an important tool for liver disease research. Gastroenterology. 2015 Nov;149(6):1361-77. PubMed PMID: 26319012; NIHMSID: NIHMS758155; PubMed Central PMCID: PMC4762709.
  

  Jacob V, Chernyavskaya Y, Chen X, Tan PS, Kent B, et al. DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Development. 2015 Feb 1;142(3):510-21. PubMed PMID: 25564650; PubMed Central PMCID: PMC4303001.
  

• 2014 Publications

  Vacaru AM, Di Narzo AF, Howarth DL, Tsedensodnom O, Imrie D, et al. Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish. Dis Model Mech. 2014 Jul;7(7):823-35. PubMed PMID: 24973751; PubMed Central PMCID: PMC4073272.
  

  Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, et al. RAF1 mutations in childhood-onset dilated cardiomyopathy. Nat Genet. 2014 Jun;46(6):635-9. PubMed PMID: 24777450; NIHMSID: NIHMS593731; PubMed Central PMCID: PMC4049514.
  

  Jacob V, Sadler KC. MKKing the most of liver regeneration: an in vivo screen identifies the MKK4 pathway as a suppressor of regeneration. Hepatology. 2014 Mar;59(3):1201-3. PubMed PMID: 24123204.  
  

  Mudbhary R, Hoshida Y, Chernyavskaya Y, Jacob V, Villanueva A, et al. UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma. Cancer Cell. 2014 Feb 10;25(2):196-209. PubMed PMID: 24486181; NIHMSID: NIHMS555063; PubMed Central PMCID: PMC3951208.
  

  Vacaru AM, Unlu G, Spitzner M, Mione M, Knapik EW, et al. In vivo cell biology in zebrafish - providing insights into vertebrate development and disease. J Cell Sci. 2014 Feb 1;127(Pt 3):485-95. PubMed PMID: 24481493; PubMed Central PMCID: PMC4007761.
  

  Howarth DL, Lindtner C, Vacaru AM, Sachidanandam R, Tsedensodnom O, et al. Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. PLoS Genet. 2014;10(5):e1004335. PubMed PMID: 24874946; PubMed Central PMCID: PMC4038464.
  

• 2013 Publications

  Tsedensodnom O, Sadler KC. ROS: redux and paradox in fatty liver disease. Hepatology. 2013 Oct;58(4):1210-2. PubMed PMID: 23703804; NIHMSID: NIHMS587451; PubMed Central PMCID: PMC4072499.
  

  Tsedensodnom O, Vacaru AM, Howarth DL, Yin C, Sadler KC. Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease. Dis Model Mech. 2013 Sep;6(5):1213-26. PubMed PMID: 23798569; PubMed Central PMCID: PMC3759341.
  

  Howarth DL, Yin C, Yeh K, Sadler KC. Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. Zebrafish. 2013 Jun;10(2):199-210. PubMed PMID: 23697887; PubMed Central PMCID: PMC3673611.
  

  Sadler KC, Rawls JF, Farber SA. Getting the inside tract: new frontiers in zebrafish digestive system biology. Zebrafish. 2013 Jun;10(2):129-31. PubMed PMID: 23738756; PubMed Central PMCID: PMC3791438.  

  Chu J, Mir A, Gao N, Rosa S, Monson C, et al. A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation. Dis Model Mech. 2013 Jan;6(1):95-105. PubMed PMID: 22899857; PubMed Central PMCID: PMC3529342.
  

• 2012 Publications

  Imrie D, Sadler KC. Stress management: How the unfolded protein response impacts fatty liver disease. J Hepatol. 2012 Nov;57(5):1147-51. PubMed PMID: 22732510; NIHMSID: NIHMS533448; PubMed Central PMCID: PMC3872997.
  

  Cline A, Gao N, Flanagan-Steet H, Sharma V, Rosa S, et al. A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency. Mol Biol Cell. 2012 Nov;23(21):4175-87. PubMed PMID: 22956764; PubMed Central PMCID: PMC3484097.
  

  Howarth DL, Vacaru AM, Tsedensodnom O, Mormone E, Nieto N, et al. Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes. Alcohol Clin Exp Res. 2012 Jan;36(1):14-23. PubMed PMID: 21790674; NIHMSID: NIHMS302773; PubMed Central PMCID: PMC3204333.
  

  Chu J, Loughlin EA, Gaur NA, SenBanerjee S, Jacob V, et al. UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis. Mol Biol Cell. 2012 Jan;23(1):59-70. PubMed PMID: 22072796; PubMed Central PMCID: PMC3248904.
  

  Gerhart SV, Eble DM, Burger RM, Oline SN, Vacaru A, et al. The Cx43-like connexin protein Cx408 is differentially localized during fin ontogeny and fin regeneration. PLoS One. 2012;7(2):e31364. PubMed PMID: 22347467; PubMed Central PMCID: PMC3275562.
  

• 2011 Publications

  Thakur PC, Stuckenholz C, Rivera MR, Davison JM, Yao JK, et al. Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish. Hepatology. 2011 Aug;54(2):452-62. PubMed PMID: 21488074; NIHMSID: NIHMS286931; PubMed Central PMCID: PMC3140628.
  

  Cinaroglu A, Gao C, Imrie D, Sadler KC. Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish. Hepatology. 2011 Aug;54(2):495-508. PubMed PMID: 21538441; NIHMSID: NIHMS291611; PubMed Central PMCID: PMC3145024.
  

  Mudbhary R, Sadler KC. Epigenetics, development, and cancer: zebrafish make their mark. Birth Defects Res C Embryo Today. 2011 Jun;93(2):194-203. PubMed PMID: 21671358; NIHMSID: NIHMS527915; PubMed Central PMCID: PMC3855246.
  

  Howarth DL, Passeri M, Sadler KC. Drinks like a fish: using zebrafish to understand alcoholic liver disease. Alcohol Clin Exp Res. 2011 May;35(5):826-9. PubMed PMID: 21284674; NIHMSID: NIHMS259110; PubMed Central PMCID: PMC3083479.
  

  Tien AL, Senbanerjee S, Kulkarni A, Mudbhary R, Goudreau B, et al. UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis. Biochem J. 2011 Apr 1;435(1):175-85. PubMed PMID: 21214517; NIHMSID: NIHMS358112; PubMed Central PMCID: PMC3291200.
  

• 2010 Publications

  Imrie D, Sadler KC. White adipose tissue development in zebrafish is regulated by both developmental time and fish size. Dev Dyn. 2010 Nov;239(11):3013-23. PubMed PMID: 20925116; NIHMSID: NIHMS260572; PubMed Central PMCID: PMC3016641.
  

  Zhao X, Monson C, Gao C, Gouon-Evans V, Matsumoto N, et al. Klf6/copeb is required for hepatic outgrowth in zebrafish and for hepatocyte specification in mouse ES cells. Dev Biol. 2010 Aug 1;344(1):79-93. PubMed PMID: 20430021; NIHMSID: NIHMS201251; PubMed Central PMCID: PMC2909330.
  

  Monson CA, Sadler KC. Inbreeding depression and outbreeding depression are evident in wild-type zebrafish lines. Zebrafish. 2010 Jun;7(2):189-97. PubMed PMID: 20438386; NIHMSID: NIHMS181816; PubMed Central PMCID: PMC2946628.
  

  Feng S, Cokus SJ, Zhang X, Chen PY, Bostick M, et al. Conservation and divergence of methylation patterning in plants and animals. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8689-94. PubMed PMID: 20395551; PubMed Central PMCID: PMC2889301.
  

• 2009 Publications

  Chu J, Sadler KC. New school in liver development: lessons from zebrafish. Hepatology. 2009 Nov;50(5):1656-63. PubMed PMID: 19693947; NIHMSID: NIHMS294156; PubMed Central PMCID: PMC3093159.
  

  Eichenbaum JW, Cinaroglu A, Eichenbaum KD, Sadler KC. A zebrafish retinal graded photochemical stress model. J Pharmacol Toxicol Methods. 2009 May-Jun;59(3):121-7. PubMed PMID: 19269339; NIHMSID: NIHMS533457; PubMed Central PMCID: PMC3884834.
  

  Passeri MJ, Cinaroglu A, Gao C, Sadler KC. Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology. 2009 Feb;49(2):443-52. PubMed PMID: 19127516; NIHMSID: NIHMS80139; PubMed Central PMCID: PMC2635426.
  

• 2008 Publications

  Toyoshima Y, Monson C, Duan C, Wu Y, Gao C, et al. The role of insulin receptor signaling in zebrafish embryogenesis. Endocrinology. 2008 Dec;149(12):5996-6005. PubMed PMID: 18687786; PubMed Central PMCID: PMC2613066.
  

  Sakaguchi TF, Sadler KC, Crosnier C, Stainier DY. Endothelial signals modulate hepatocyte apicobasal polarization in zebrafish. Curr Biol. 2008 Oct 28;18(20):1565-71. PubMed PMID: 18951027; NIHMSID: NIHMS117620; PubMed Central PMCID: PMC2720033.
  

• 2007 and Earlier Publications

  Sadler KC, Krahn KN, Gaur NA, Ukomadu C. Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1570-5. PubMed PMID: 17242348; PubMed Central PMCID: PMC1785278.
  

  Sadler KC, Amsterdam A, Soroka C, Boyer J, Hopkins N. A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. Development. 2005 Aug;132(15):3561-72. PubMed PMID: 16000385.
  

  Hamaratoğlu F, Eroğlu A, Toner M, Sadler KC. Cryopreservation of starfish oocytes. Cryobiology. 2005 Feb;50(1):38-47. PubMed PMID: 15710368.
  

  Amsterdam A, Sadler KC, Lai K, Farrington S, Bronson RT, et al. Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol. 2004 May;2(5):E139. PubMed PMID: 15138505; PubMed Central PMCID: PMC406397.
  

  Sadler KC, Yüce O, Hamaratoglu F, Vergé V, Peaucellier G, et al. MAP kinases regulate unfertilized egg apoptosis and fertilization suppresses death via Ca2+ signaling. Mol Reprod Dev. 2004 Mar;67(3):366-83. PubMed PMID: 14735498.
  

  Sadler KC. Attention, neurons, this CDK could save your life!. Trends Cell Biol. 2002 May;12(5):214. PubMed PMID: 12062166.