Combining microprinting and microfluidics, we are developing a highly multiplexed ultrasensitive detection device for clinically-relevant biomarkers.The goal of our current project is to enhance the detection capabilities of a diagnostic microarray platform for analysis of nucleic acids using a microfluidic concentration module. Without using PCR, the microfluidic concentrator will increase the DNA or RNA sample concentration locally at the site of detection and thus, enable fast and sensitive detection of low-abundant sequences. This concentrator-enhanced microarray will open up a new possibility to measure gene transcripts with low expression levels that have been difficult to deal with conventional microarray platforms.