Prior to any biosensing/detection, an efficient preparation is required to reduce the sample complexity and to increase the detection sensitivity of a biosensor. We utilize colloidal particles to build a high-aspect-ratio biomimetic nanostructure for the separation of biomolecules inside a BioMEMS device.
Combining microprinting and microfluidics, we are developing a highly multiplexed ultrasensitive detection device for clinically-relevant biomarkers. The goal of our current project is to enhance the detection capabilities of a diagnostic microarray platform for analysis of nucleic acids using a microfluidic concentration module.
Microfluidic devices offer several advantages for cell biology such as high-throughput screening, portability, inexpensive platform and reduced sample volume and reagents. The use of microfluidic chips can be extended beyond mammalian cells to any microorganisms such as algae and E. coli.
