Cell Fate and Differentiation

A central aim of the laboratory is to define how nuclear organization directs cell fate transitions.

We have demonstrated that in the cell nucleus cytoskeletal proteins operate at the chromatin level across major differentiation pathways, including adipogenesis, osteogenesis and neurogenesis. Our ongoing work examines how chromatin remodeling interfaces with pluripotency networks, extracellular matrix signaling and cellular mechanics through the lenses of actin and myosin motors.

This framework seeks to explain how molecular and physical cues converge to establish stable cellular identities.