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Publications

Selected Recent Publications

Campbell CR, Hosny El Said N, Ghassan Al Nuairi A, Loganathan P, Breunig C, Deliorman M, Desbordes SC, Lohse MJ, Magzoub M, Qasaimeh MA, Percipalle P. Nuclear β-actin–dependent chromatin accessibility governs stem cell pluripotency and extracellular matrix gene programs to maintain cellular biomechanics for cell lineage decisions. BioRxiv 2026/in review.

 

Khalaji S, Venit T, Lukáčová Z, Fambri V, Shrestha R, Kaluarachchi S, Boitet M, Fagny M, Saldi G, Percipalle P. Nuclear Myosin 1 links genomic architecture to adipose tissue remodeling, metabolic inflammation and obesity in mice. Cell Death Dis. 2026 Feb 26;17(1):270.

 

Hosny El Said N, Abdrabou W, Mahmood SR, Venit T, Idaghdour Y, Percipalle P. Nuclear actin-dependent Meg3 expression suppresses metabolic genes by affecting the chromatin architecture at sites of elevated H3K27 acetylation levels. Nucleic Acids Res. 2025 Apr 10;53(7):gkaf280.

 

Venit T, Khalaji S, Fambri V, Abdrobou W, El Gindi M, Shrestha R, Hozak P, Idaghdour Y, Teo JCM, Percipalle P. Loss of nuclear myosin 1 causes hemostatic defects and immune dysregulation. Haematologica. 2026 May 1;111(5):1804-1809. 

 

Venit T, Sapkota O, Abdrabou WS, Loganathan P, Pasricha R, Mahmood SR, El Said NH, Sherif S, Thomas S, Abdelrazig S, Amin S, Bedognetti D, Idaghdour Y, Magzoub M, Percipalle P. Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice. Nat Commun. 2023 Oct 10;14(1):6328. 

 

Mahmood SR, Said NHE, Gunsalus KC, Percipalle P. β-actin mediated H3K27ac changes demonstrate the link between compartment switching and enhancer-dependent transcriptional regulation. Genome Biol. 2023 Jan 25;24(1):18.

 

Mahmood SR, Xie X, Hosny El Said N, Venit T, Gunsalus KC, Percipalle P. β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture. Nat Commun. 2021 Sep 2;12(1):5240.

 

Venit T, Semesta K, Farrukh S, Endara-Coll M, Havalda R, Hozak P, Percipalle P.Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism. Commun Biol. 2020 Mar 11;3(1):115.

 

Al-Sayegh MA, Mahmood SR, Khair SBA, Xie X, El Gindi M, Kim T, Almansoori A, Percipalle P. β-actin contributes to open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprograming. Mol Biol Cell. 2020 Nov 1;31(23):2511-2521.

 

Gjorgjieva T, Xie X, Commins P, Pasricha R, Mahmood SR, Gunsalus KC, Naumov P, Percipalle P. Loss of β-Actin Leads to Accelerated Mineralization and Dysregulation of Osteoblast-Differentiation Genes during Osteogenic Reprogramming. Adv Sci (Weinh). 2020 Oct 27;7(23):2002261.

 

Xie X, Almuzzaini B, Drou N, Kremb S, Yousif A, Farrants AÖ, Gunsalus K, Percipalle P.β-Actin-dependent global chromatin organization and gene expression programs control cellular identity. FASEB J. 2018 Mar;32(3):1296-1314.

 

Xie X, Jankauskas R, Mazari AMA, Drou N, Percipalle P. β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. PLoS Genet. 2018 Dec 17;14(12):e1007846.