Sadler Edepli Lab

Our research uses whole animals to explore fundamental properties of developing, regenerating and diseased cells. Some of the central questions we address are:

  • How does global reorganization of the genome and epigenome influence cell division, regeneration and cancer?
  • How does the cellular response to endoplasmic reticulum (ER) stress adapt cells in the liver to additional stress? 
  • How does this adaptive response get converted to a pathological response to cause fatty liver?
  • How do environmental exposures synergize to cause liver disease?

Despite the remarkable regenerative capacity of the liver, it is not always able to undergo efficient repair. Thus, diseases of the liver are common and a long-term goal of our research is to identify targets to treat them. We use zebrafish as a model system to accomplish these goals.