Gennaro Esposito , Yamanappa Hunashal, Mathias Percipalle , Tomas Venit, Mame Massar Dieng ,Federico Fogolari , Gholamreza Hassanzadeh, Fabio Piano, Kristin C Gunsalus, Youssef Idaghdour,Piergiorgio Percipalle (2021) NMR-Based Analysis of Nanobodies to SARS-CoV-2 Nsp9 Reveals a Possible Antiviral Strategy Against COVID-19.Adv Biol (Weinh) .
Wael Abdrabou , Mame Massar Dieng, Aïssatou Diawara,Samuel Sindié Sermé, Dareen Almojil, Salif Sombié, Noelie Bere Henry,Désiré Kargougou ,Vinu Manikandan,Issiaka Soulama,Youssef Idaghdour (2021) Metabolome modulation of the host adaptive immunity in human malaria. Nat Metab
G. H. Souza Bomfim, V. Costiniti, Y. Li, Y. Idaghdour and R. S. Lacruz (2020) TRPM7 activation potentiates SOCE in enamel cells but requires ORAI. Cell Calcium
Abiola Senok , Hanan Alsuwaidi , Yusrah Atrah , Ola Al Ayedi , Janan Al Zahid , Aaron Han, Asma Al Marzooqi, Saba Al Heialy , Basel Altrabulsi , Laila AbdelWareth , Youssef Idaghdour, Raghib Ali, Tom Loney, Alawi Alsheikh-Ali (2020) Saliva as an Alternative Specimen for Molecular COVID-19 Testing in Community Settings and Population-Based Screening. Infect Drug Resist
Souza Bomfim GH, Costiniti V, Li Y, Idaghdour Y, Lacruz RS (2020) TRPM7 activation potentiates SOCE in enamel cells but requires ORAI. Cell Calcium.
Mame Massar Dieng, Aïssatou Diawara ,Vinu Manikandan, Hala Tamim El Jarkass, Samuel Sindié Sermé, Salif Sombié, Aïssata Barry, Sam Aboubacar Coulibaly, Amidou Diarra , Nizar Drou, Marc Arnoux, Ayman Yousif, Alfred B Tiono, Sodiomon B Sirima, Issiaka Soulama , Youssef Idaghdour (2020) Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria. Nat Commun
Yi Jin Liew, Emily J. Howells, Xin Wang, Craig T. Michell, John A. Burt, Youssef Idaghdour & Manuel Aranda (2020) .Intergenerational epigenetic inheritance in reef-building corals.Nature Climate Change volume 10, pages254–259 doi: 10.1038/s41558-019-0687-2
Francisco J Aulestia, Johnny Groeling, Guilherme H S Bomfim, Veronica Costiniti , Vinu Manikandan, Ariya Chaloemtoem , Axel R Concepcion, Yi Li, Larry E Wagner 2nd, Youssef Idaghdour, David I Yule, Rodrigo S Lacruz . Fluoride exposure alters Ca(2+) signaling and mitochondrial function in enamel cells. Sci Signal (2020).
Aminah Tasnim Ali, Youssef Idaghdour & Alan Hodgkinson. Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes. Commun Biol 3, 147 (2020). doi:10.1038/s42003-020-0879-3
van der Wijst MG, de Vries DH, Groot HE, Trynka G, Hon CC, Bonder MJ, Stegle O, Nawijn M, Idaghdour Y, van der Harst P, Ye CJ, Powell J, Theis FJ, Mahfouz A, Heinig M, Franke L. The single-cell eQTLGen consortium. Elife. (2020) Mar 9;9. pii:e52155. doi: 10.7554/eLife.52155.
Sasan Rabieh, Odmaa Bayaraa, Emarosa Romeo, Patila Amosa, Khemet Calnek, Youssef Idaghdour, Michael A Ochsenkühn, Shady A Amin , Gary Goldstein, Timothy G Bromage. MH-ICP-MS Analysis of the Freshwater and Saltwater Environmental Resources of Upolu Island, Samoa. Molecules (2020)
Wilcox JJS, Boissinot S, Idaghdour Y. Falcon genomics in the context of conservation, speciation, and human culture. Ecol Evol. (2019) Dec 7;9(24):14523-14537. doi: 10.1002/ece3.5864.
Zeng B, Lloyd-Jones LR, Montgomery GW, Metspalu A, Esko T, Franke L, Vosa U, Claringbould A, Brigham KL, Quyyumi AA, Idaghdour Y, Yang J, Visscher PM, Powell JE, Gibson G. Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation. Genetics. (2019) Jul;212(3):905-918. doi:10.1534/genetics.119.302091.
Eckstein M, Vaeth M, Aulestia FJ, Costiniti V, Kassam SN, Bromage TG, Pedersen P, Issekutz T, Idaghdour Y, Moursi AM, Feske S, Lacruz RS. Differential regulation of Ca(2+) influx by ORAI channels mediates enamel mineralization. Sci Signal. (2019) doi: 10.1126/scisignal.aav4663.
Favé MJ, Lamaze FC, Soave D, Hodgkinson A, Gauvin H, Bruat V, Grenier JC,Gbeha E, Skead K, Smargiassi A, Johnson M, Idaghdour Y, Awadalla P.Gene-by-environment interactions in urban populations modulate risk phenotypes. Nat Commun. (2018) doi: 10.1038/s41467-018-03202-2.
Biao Zeng, Luke R. Lloyd-Jones, Alexander Holloway, Urko M. Marigorta, Andres Metspalu, Grant W. Montgomery, Tonu Esko, Kenneth L. Brigham, Arshed A. Quyyumi, Idaghdour Y, Yang J, Visscher PM, Powell JE,Gibson G. Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression. G3 (Bethesda). (2017). doi:10.1534/g3.117.043752.
Zeng B, Lloyd-Jones LR, Holloway A, Marigorta UM, Metspalu A, Montgomery GW,Esko T, Brigham KL, Quyyumi AA, Idaghdour Y, Yang J, Visscher PM, Powell JE,Gibson G. Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression. G3 (Bethesda). (2017). doi:10.1534/g3.117.043752.
Youssef Idaghdour and Alan Hodgkinson (2017) Integrated genomic analysis of mitochondrial RNA processing in human cancers. Genome Medicine.20179:36. doi:10.1186/s13073-017-0426-0
Miriam Eckstein, Martin Vaeth, Cinzia Fornai, Manikandan Vinu, Timothy G. Bromage, Meerim K. Nurbaeva, Jessica L. Sorge, Paulo G. Coelho, Youssef Idaghdour, Stefan Feske and Rodrigo S. Lacruz (2017) Store-operated Ca2+ entry controls ameloblast cell function and enamel development. JCI Insight. 2(6):e91166. doi:10.1172/jci.insight.91166
Momparler RL, Côté S, Momparler LF and Idaghdour Y (2017) Inhibition of DNA and Histone Methylation by 5-Aza-2'-deoxycytidine (Decitabine) and 3-Deazaneplanocin-A on Antineoplastic Action and Gene Expression in Myeloid Leukemic Cells. Frontiers in Oncology. 7:19. doi.org/10.3389/fonc.2017.00019
Gomez S, Diawara A, Gbeha E, Awadalla P, Sanni A, Idaghdour Y* and Rahimy MC* (2016) Comparative Analysis of Iron Homeostasis in Sub-Saharan African Children with Sickle Cell Disease and Their Unaffected Siblings. Front. Pediatr. 4:8. doi: 10.3389/fped.2016.00008
Ketchum, R.N, Dieng, M.M, Vaughan, G.O, Burt, J.A.*, Idaghdour Y* (2015) Levels of genetic diversity and taxonomic status of Epinephelus species in United Arab Emirates fish markets. Marine Pollution Bulletin. http://dx.doi.org/10.1016/j.marpolbul.2015.11.042
Bromage TG, Idaghdour Y, Lacruz RS, Crenshaw TD, Ovsiy O, Rotter B, Hoffmeier K, Schrenk F(2016) The Swine Plasma Metabolome Chronicles "Many Days" Biological Timing and Functions Linked to Growth. PLoS One. doi:10.1371/journal.pone.0145919
Hussin JG, Hodgkinson A, Idaghdour Y, Grenier JC, Goulet JP, Gbeha E, Hip-Ki E, Awadalla (2015) Recombination affects accumulation of damaging and disease-associated mutations in human populations. Nature Genetics. doi: 10.1038/ng.3216
Momparler RL, Côté S, Momparler LF, Idaghdour Y (2014) Epigenetic therapy of acute myeloid leukemia using 5-aza-deoxycetadine (decitabine) in combination with inhibitors of histone methylation and deacetylation. Clinical Epigenetics. 6:19. doi: 10.1186/1868-7083-6-19.
Hodgkinson A*, Idaghdour Y*, Gbeha E, Grenier JC, Hip-Ki, Goulet JP, Bruat V, de Malliard T, Awadalla P (2014) High Resolution Genomic Analysis of Human Mitochondrial Sequence Variation. Science. 344(6182):413-5. doi: 10.1126/science.1251110. *equal contribution.
Quinlan J*, Idaghdour Y*, Goulet JP, Gbeha E, de Malliard T, Bruat V, Grenier JC, Gomez S, Sanni A, Rahimy MC, Awadalla P (2014) Genomic architecture of sickle cell disease in West African children. 14;5:26. doi: 10.3389/fgene.2014.00026. Frontiers in Genetics .*equal contribution.
Hodgkinson A, Casals F, Idaghdour Y, Grenier JC, Hernandez RD, Awadalla P (2013) Selective constraint, background selection, and mutation accumulation variability within and between human populations. BMC Genomics. 14:495 doi:10.1186/1471-2164-14-495.
Casals F, Hodgkinson A, Hussin J, Idaghdour Y, Bruat V, de Maillard T, Grenier JC, Gbeha E, Hamdan FF, Girard S, Spinella JF, Larivière M, Saillour V, Healy J, Fernández I, Sinnett D, Michaud JL, Rouleau GA, Haddad E, Le Deist F, Awadalla P (2013) Whole-Exome Sequencing Reveals a Rapid Change in the Frequency of Rare Functional Variants in a Founding Population of Humans. PLoS Genetics. 9(9): e1003815. doi:10.1371/journal.pgen.1003815.
Diawara A, Halpenny CM, Churcher TS, Mwandawiro C, Kihara J, Kaplan RM, Streit TG, Idaghdour Y, Scott ME, Basáñez MG, Prichard RK. (2013) Association between Response to Albendazole Treatment and β-Tubulin Genotype Frequencies in Soil-transmitted Helminths. PLoS Neglected Tropical Diseases 7(5): e2247. doi:10.1371/journal.pntd.0002247
Preininger M, Arafat D, Kim J, Nath AP, Idaghdour Y, Brigham KL, Gibson G (2013) Blood-informative transcripts define nine common axes of peripheral blood gene Expression. PLoS Genetics. e1003362. doi:10.1371/journal.pgen.1003362
Samuels ME, Majewski J, Alirezaie N, Fernandez I, Casals F, Patey N, Decaluwe H, Gosselin I, Haddad E, Hodgkinson A, Idaghdour Y, Marchand V, Michaud JL, Rodrigue M, Desjardins S, Dubois S, Le Deist F, Awadalla P, Raymond V, Maranda B (2013) Exome sequencing identifies mutations in the gene TTC7A in French-Canadian cases with hereditary multiple intestinal atresia. Journal of Medical Genetics. 10.1136/jmedgenet
Hussin J, Sinnett D, Casals F, Idaghdour Y, Bruat V, Saillour V, Healy J, Grenier JC, de Malliard T, Spinella JF, Lariviere M, Busche S, Gibson G, Andersson A, Holmfeldt L, Ma J, Wei L, Zhang J, Andelfinger G, Downing J, Mullighan C and Awadalla P (2012) Rare allelic forms of PRDM9 associated with childhood leukemogenesis. Genome Research. doi:10.1101/gr.144188.112
Idaghdour Y and Awadalla P (2012) Exploiting gene expression variation to capture gene-environment interactions for disease. Frontiers in Genetics 3:228. doi: 10.3389/fgene.2012.00228.
Awadalla P, Boileau C, Payette Y, Idaghdour Y, Goulet JP, Knoppers B, Hamet P, Laberge C on behalf of the CARTaGENE Project (2012) Cohort profile of the CARTaGENE study: Quebec’s population-based biobank for public health and personalized genomics. International Journal of Epidemiology. doi: 10.1093/ije/dys160.
Idaghdour Y, Quinlan J, Goulet JP, Berghout J, Gbeha E, Bruat V, de Malliard T, Grenier JC, Gomez S, Gros P, Rahimy MC, Sanni A and Awadalla P (2012) Evidence for additive and interaction effects of host genotype and infection in malaria. PNAS 109(42): 16786-16793. Feature Article + Cover.
Momparler RL, Idaghdour Y, Marquez VE and Momparler LF (2012) Synergistic antileukemic action of a combination of inhibitors of DNA methylation and histone methylation. Leukemia Research 36(8):1049-54.
Casals F, Idaghdour Y, Hussin J and Awadalla P (2012) Next-generation sequencing approaches for genetic mapping of complex diseases. J Neuroimmunol 248: 10-22.
Review Article.
Conrad DF, Keebler J, DePristo M, Lindsay SJ, Zhang Y, Casals F, Idaghdour Y, Torroja C, Hartl C, Garimella K, Zilversmit M, Cartwright R, Rouleau G, Daly M, Stone EA, Hurles ME, Awadalla P on behalf of the 1000 Genomes Project (2011) Variation in genome-wide mutation rates within and between human families. Nature Genetics 43(7): 712-4.
Dworkin I, Anderson JA, Idaghdour Y, Kennerly, EM, Stone EA and Gibson G (2011) The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc, and its association with wing shape in Drosophila melanogaster. Genetics 187(4): 1171-84.
The 1000 Genomes Consortium* (2010, Idaghdour Y coauthor) A map of human genome variation from population scale sequencing. Nature 467: 1061-1073.
Idaghdour Y, Czika W, Shianna K, Lee H, Visccher PM, Martin H, Miclaus K, Jadallah S, Goldstein DB, Wolfinger RD and Gibson G (2010) Geographical Genomics of Human Leukocyte Gene Expression Variation in Southern Morocco. Nature Genetics 42(1): 62-67.
Gibson G, Idaghdour Y, Czika W, Miclaus K, Lee SH, Visscher PM and Wolfinger RD (2010) Accounting for population structure and relatedness in gene expression genome-wide association testing using a mixed-model approach. Protocol Exchange. 10.1038/nprot.2009.216.
Kennerly EM, Idaghdour Y, Olby NJ, Osborne JN and Gibson G (2009) Pharmacogenetic Association Study of 30 genes with Phenobarbital Drug Response in Epileptic Dogs. Pharmacogenomics and Genetics 19(12): 911-922.
Chbel F, Broderick D, Idaghdour Y, Korrida A and McCormick P (2002) Characterization of 22 microsatellites loci from the endangered Houbara bustard (Chlamydotis undulata undulata). Molecular Ecology Notes 2(4): 484-87.
Idaghdour Y, Storey JD, Jadallah SJ and Gibson G (2008) A Genome-wide Gene Expression Signature of Lifestyle and Geography in Leukocytes of Moroccan Amazighs. PLoS Genetics 4(4): e1000052.
Idaghdour Y, Broderick D, Korrida A and Chbel F (2004) Mitochondrial control region diversity of the houbara bustard Chlamydotis undulata complex and genetic structure along the Atlantic seaboard of North Africa. Molecular Ecology 13(1): 43-54.
Idaghdour Y, Broderick D and Korrida A (2003) Faeces as a source of DNA for molecular studies into a threatened population of great bustards in Morocco. Conservation Genetics 4(6): 789-792.
Broderick D, Idaghdour Y, Korrida A & Hellmich J (2003) Gene flow in great bustard populations across the Straits of Gibraltar as elucidated from excremental PCR and mtDNA sequencing. Conservation Genetics 4(6): 793-800.
Alonso JC Lane SJ, Dawson R and Idaghdour Y (1999) Great bustards Otis tarda in Morocco: status in spring 1999 and evidence of a decline in recent decades. Oryx 34 (2): 141-146.
