Our research focuses on one of the most intimate coevolutionary interactions: the interaction between a genome and its intra-genomic parasites, transposable elements. The term "transposable element" (TE) covers an extremely large diversity of mobile sequences that replicate with an RNA intermediate (e.g. retrotransposons) or without (e.g. DNA transposons).
In the course of our research on transposable element solution, we realized that if we were to fully understand the dynamics of amplification of TEs in our model, the green anole lizard (Anolis carolinensis), it was necessary to know the population structure and demographic history of the species.
One of the major questions in infectious disease research is: why do some individuals get sick, while others remain healthy or mildly affected by viral infection? The genetic background of individuals significantly influences the outcome of viral infection and he oligo-adenylate (OAS) pathway has been shown to play a major role in this process.