Τhe talk will focus on the impressive evolution of AI and the unique opportunities it unravels for Health. From hospital care to clinical research, drug discovery and health insurance, AI applications are expected to radically impact healthcare, reducing costs and improving patient care. What prospects are opened up through large-scale data aggregation, increased computational power, and improved algorithm performance? How does the transformative power of AI expand from self-care to hospital care, from prediction, prevention and diagnosis to effective disease treatment? Which challenges need to be addressed so that AI systems are aligned with human value requirements, with the ultimate goal of securing health and wellness. In this talk, we will discuss various aspects of the AI healthcare landscape by presenting state-of-the-art AI-empowered solutions that enable informed, more accurate diagnosis, timely prognosis, and effective treatment planning, underpinning precision medicine. An overview of different contemporary and emerging AI algorithmic methods for disease modelling will be provided, focusing on machine learning and deep learning architectures, that have already become the de facto approach in a variety of healthcare applications. Personal health systems that leverage these approaches for the early detection, assessment and effective management of highly prevalent diseases, ranging from diabetes, obesity, and cardiovascular disease to neurological disorders, will be outlined. The talk will highlight the challenges, limitations, and best practices for the development, adoption, and maintenance of AI systems in healthcare, by placing emphasis on the concept of model transparency, that state-of the-art interpretability and explainability methods can realize. Enhancing human understanding, maximizing user trust, and ensuring ethically aligned systems can pave the way for the true adoption of AI in clinical practice.