Filipe Pinto Teixeira

Research Scientist Affiliation: NYU Abu Dhabi
Education: PhD, (Cum Laude) Universitat Pompeu Fabra; MSc, Faculdade de Ciências, Universidade de Lisboa, Lisbon;

Filipe Pinto Teixeira is a developmental neurobiologist interested in sensory biology and how neural circuits develop to support sensory processing.

He received his PhD from the University Pompeu Fabra in Barcelona on his work in the development and regeneration of the Zebrafish Lateral Line Sensory System, at the Centre for Genomic Regulation (CRG) in Barcelona in the laboratory of Dr. Hernán López-Schier.

In 2012 he joined the Center of Genomics and System Biology as a Postdoctoral fellow. At the Center, he has been studying neural specification and circuit formation using the fruit fly optic lobe as a model system.

Filipe Pinto Teixeira is the Atip-Avenir Fondation Bettencourt Schueller 2019 Laureate.


How is the adult Central Nervous System neuronal diversity produced from an apparent uniform pool of embryonic progenitors and how the emerging and functional characteristics of different neuronal populations relate to their developmental origin. Neuronal diversity can be achieved by the temporal patterning of neural stem cells. Recent work from the Desplan lab has shown that, like in the ventral nerve cord of Drosophila, a temporal progression of transcription factors in the progenitor cells (neuroblasts) of the developing medulla of the Drosophila optic lobe instructs the orderly production of different neuronal types. Interestingly, in the developing medulla, the transcription factors used in the temporal sequence are different from those in the ventral nerve cord. This suggests that temporal patterning of neuroblasts is a universal strategy used for neuronal specification, with different transcription factor sequences being recruited in different systems. Whether and how the same mechanism is used for other optic lobe and brain neuropils is not known. Here we address this question by investigating neurogenesis in the Inner Proliferation Center (IPC), a region of the Drosophila larval brain that gives rise to the Lobula neuropil, the next processing center that receives inputs from the medulla.

Our initial observations suggest that the neuroblasts from the IPC do not switch expression of their transcription factor and instead are patterned mostly by spatial cues. Therefore, IPC neurogenesis provides a unique opportunity to test how universal the temporal patterning strategy is, and to investigate how other optic lobe neuropils use spatial patterning for the neuronal specification.

Furthermore, we aim at understanding how the combinatorial code of transcription factors and downstream cell surface proteins in a developing neuron relates to its emerging and functional characteristics. For this, I am using the fly motion detection circuitry as a model.