Publications

Deodato, D.; Asad, N.; Dore, T. M. Photoactivatable AMPA for the Study of Glutamatergic Neuronal Transmission Using Two-Photon Excitation. Org. Biomol. Chem. 2021, 19, 5589-5594.
PMID: 34086030

Rodriguez-Contreras, D.; Condon, A. F.; Buck, D. C.; Asad, N.; Dore, T. M.; Verbeek, D. S.; Tijssen, M. A. J.; Shinde, U.; Williams, J. T.; Neve, K. A. Signaling-Biased and Constitutively Active Dopamine D2 Receptor Variant. ACS Chem. Neurosci. 2021, 12, 1873-1884.
PMID: 33974399

Gore, S.; Ukhanov, K.; Herbivo, C.; Asad, N.; Bobkov, Y. V.; Martens, J. R.; Dore, T. M. Photoactivatable Odorants for Chemosensory Research. ACS Chem. Biol. 2020, 15, 2516-2528.
PMID: 32865973

Deodato, D.; Dore,. T. M. Practical Synthesis of Quinoline-Protected Morpholino Oligomers for Light-Triggered Regulation of Gene Function. Molecules 2020, 25, 2078.
PMID:  32365635

Asad, N.; McLain, D. E.; Condon, A. F.; Gore. S.; Hampton, S. E.; Vijay, S.; Williams, J. T.; Dore. T. M. Photoactivatable Dopamine and Sulpiride to Explore the Function of Dopaminergic Neurons and Circuits. ACS Chem. Neurosci. 2020, 11, 939-951.
PMID:  32077679
PMCID: PMC7101055

Sharma, S. K.; Vijay, S.; Gore, S.; Dore, T. M.; Jagannathan, R. Measuring Cellular Ion Transport by Magnetoencephalography. ACS Omega 2020, 5, 4024-4031.
PMID: 32149229

Hennig, A.-L. K.; Deodato, D.; Asad, N.; Herbivo, C.; Dore, T. M. Two-Photon Excitable Photoremovable Protecting Groups Based on the Quinoline Scaffold for Use in Biology. J. Org. Chem. 2020, 85,  726-744.
PMID: 31808339

Deodato, D.; Asad, N.; Dore, T. M. Photorearrangement of Quinoline-Protected Dialkylanilines and the Photorelease of Aniline-Containing Biological Effectors. J. Org. Chem. 2019, 84, 7342-7353.
PMID: 31095378

O'Connor, M. J.; Beebe, L. L.; Deodato, D.; Ball, R. E.; Page, A. T.; VanLeuven, A. J.; Harris, K. T.; Park, S.; Hariharan, V.; Lauderdale, J. D.; Dore, T. M. Bypassing Glutamic Acid Decarboxylase 1 (Gad1) Induced Craniofacial Defects with a Photoactivatable Translation Blocker Morpholino. ACS Chem. Neurosci. 2019, 10, 266-278.
PMID: 30200754
PMCID: PMC6337688

Asad, N., Deodato, D., Lan, X., Widegren, M. B., Phillips, D. L., Du, L., & Dore, T. M.. Photochemical Activation of Tertiary Amines for Applications in Studying Cell Physiology. J. Am. Chem. Soc. 2017, 139, 12591-12600.
PMID: 28806084

Huang, J.; Muliawan, A. P.; Ma, J.; Li, M. D.; Chiu, H. K.; Lan, X.; Deodato, D.; Phillips, D. L.; Dore, T. M. A spectroscopic study of the excited state proton transfer processes of (8-bromo- 7-hydroxyquinolin-2-yl)methyl-protected phenol in aqueous solutions. Photochem. Photobiol. Sci. 2017, 16, 575-584.
PMID: 28145542

Jesus, A. R.; Vila-Viçosa, D.; Machuqueiro, M.; Marques, A. P.; Dore, T. M.; Rauter, A. P. Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation. J. Med. Chem. 2017, 60, 568-579.
PMID: 28098449

Ma, J.; Mewes, J.-M.; Harris, K. T.; Dore, T. M.; Phillips, D. L.; Dreuw, A. Unravelling the early photochemical behavior of (8-substituted-7-hydroxyquinolinyl)methylacetates through electronic structure theory and ultrafast transient absorption spectroscopy. Phys. Chem. Chem. Phys. 2017, 19, 1089-1096.
PMID: 27942621

Mohammed, I.; Hampton, S. E.; Ashall, L.; Hildebrandt, E. R.; Kutlik, R. A.; Manandhar, S. P.; Floyd, B. J.; Smith, H. E.; Dozier, J. K.; Distefano, M. D.; Schmidt, W. K.; Dore, T. M. 8-Hydroxyquinoline-Based Inhibitors of the Rce1 Protease Disrupt Ras Membrane Localization in Human Cells. Bioorg. Med. Chem. 2016, 24, 160-178.
PMID: 26706114
PMCID: PMC4749511

McLain, D. E.; Rea, A. C.; Widegren, M. B.; Dore, T. M. Photoactivatable, biologically-relevant phenols with sensitivity toward 2-photon excitation. Photochem. Photobiol. Sci. 2015, 14, 2151-2158.
PMID: 26467796
PMCID: PMC4661061

Vandenberg, L., N.; Blackiston, D. J.; Rea, A. C.; Dore, T. M.; Levin, M. Left-Right Patterning in Xenopus Conjoined Twin Embryos Requires Serotonin Signaling and Gap Junctions. Int. J. Dev. Biol. 2014, 58, 799-809.
PMID: 25896280

Rea, A. C.; Vandenberg, L. N.; Ball, R. E.; Snouffer, A. A.; Hudson, A.; Zhu, Y.; McLain, D. E.; Johnston, L. L.; Lauderdale, J. D.; Levin, M.; Dore, T. M. Light Activated Serotonin for Exploring Its Action in Biological Systems. Chem. Biol. 2013, 20, 1536-1546.
PMID: 24333002
PMCID: PMC3909739

Ma, J.; Rea, A. C.; An, H.; Ma, C.; Guan, X.; Li, M.-D.; Su, T.; Yeung, C. S.; Harris, K. T.; Zhu, Y.; Nganga, J. L.; Fedoryak, O. D.; Dore, T. M.; Phillips, D. L. Unraveling the Mechanism of the Photodeprotection Reaction of 8-Bromo- and 8-Chloro-7-hydroxyquinoline Caged Acetates. Chem.—Eur. J. 2012, 18, 6854-6865. 
PMID: 22511356
PMCID: PMC3531613

Abate-Pella, D.; Zeliadt, N. A.; Ochocki, J. D.; Warmka, J. K.; Dore, T. M.; Blank, D. A.; Wattenberg, E. V.; Distefano, M. D. Photochemical Modulation of Ras-Mediated Signal Transduction Using Caged Farnesyltransferase Inhibitors: Activation via One- and Two-Photon Excitation. ChemBioChem. 2012, 13, 1009-1016.
PMID: 22492666
PMCID: PMC3436068

Ma, J.; Cheng, S. C.; An, H.; Li, M.-D.; Ma, C.; Rea, A. C.; Zhu, Y.; Nganga, J. L.; Dore, T. M.; Phillips, D. L. Comparison of the Absorption, Emission, and Resonance Raman Spectra of 7-Hydroxyquinoline and 8-Bromo-7-Hydroxyquinoline Caged Acetate. J. Phys. Chem. A 2011, 115, 11632–11640.
PMID: 21905734

Dechert, A.-M.; MacNamara, J. P.; Breevoort, S. R.; Hildebrandt, E. R.; Hembree, N. W.; Rea, A. C.; McLain, D. E.; Porter, S. B.; Schmidt, W. K.; Dore, T. M. Modulation of the Inhibitor Properties of (Acyloxy)methyl Ketones Toward the CaaX Proteases. Bioorg. Med. Chem. 2010, 18, 6230-6237.
PMID: 20696584
PMCID: PMC2932464

Pirrung, M. C.; Dore, T. M.; Zhu, Y.; Rana, V. S. Sensitized Two-Photon Photochemical Deprotection. Chem. Commun. 2010, 46, 5313-5315.
PMID: 20552130

An, H.-L.; Ma, C.; Li, W.; Harris, K. T.; Dore, T. M.; Phillips, D. L. Resonance Raman Characterization of the Different Forms of Ground-State 8-Substituted 7-Hydroxyquinoline Caged Acetate Compounds in Aqueous Solutions. J. Phys. Chem. A 2010, 114, 2498-2505.
PMID: 20113003

An, H.-Y.; Ma, C.; Nganga, J. L.; Zhu, Y.; Dore, T. M.; Phillips, D. L. Resonance Raman Characterization of Different Forms of Ground-State 8-Bromo-7-hydroxyquinoline Caged Acetate in Aqueous Solutions. J. Phys. Chem. A 2009, 113, 2831-2837.
PMID: 19296708

Davis, M. J.; Kragor, C. H.; Reddie, K. G.; Wilson, H. C.; Zhu, Y.; Dore, T. M. Substituent Effects on the Sensitivity of a Quinoline Photoremovable Protecting Group to One- and Two-Photon Excitation. J. Org. Chem. 2009, 74, 1721-1729.
PMID: 19140722

Porter, S. B.; Hildebrandt, E. R.; Breevoort, S. R.; Mokry, D. Z.; Dore, T. M.; Schmidt, W. K.  Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.  Biochim. Biophys. Acta 2007, 1773, 853-862.
PMID: 17467817

Reddie, K. G.; Roberts, D. R.; Dore, T. M. Inhibition of Kinesin Motor Proteins by Adociasulfate-2.  J. Med. Chem. 2006, 49, 4857-4860.
PMID: 16884297

Zhu, Y.; Pavlos, C. M.; Toscano, J. P.; Dore, T. M.  8-Bromo-7-hydroxyquinoline as a Photoremovable Protecting Group for Physiological Use: Mechanism and Scope.  J. Am. Chem. Soc. 2006, 128, 4267-4276.
PMID: 16569001

Goard, M. P.; Aakalu, G.; Fedoryak, O. D.; Quinonez, C.; St. Julien, J.; Poteet, S. J.; Schuman, E.M.; Dore, T. M.  Light-Mediated Inhibition of Protein Synthesis.  Chem. Biol. 2005, 12, 685-693.
PMID: 15975514

Furuta, T.; Takeuchi, H.; Takahashi, Y.; Sugimoto, M.; Dore, T. M.; Kanehara, M.; Watanabe, T.; Kurahashi, T.; Iwamura, M.; Tsien, R. Y.  Bhc-cNMPs as Either Water-Soluble or Membrane-Permeant Caged Cyclic Nucleotides.  ChemBioChem 2004, 5, 1119-1128.
PMID: 15300837

Dooley, C. T.; Dore, T. M.; Hanson, G. T.; Jackson, W. C.; Remington, S. J.; Tsien, R. Y.  Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators.  J. Biol. Chem. 2004, 279, 22284-22293.
PMID: 14985369

Lu, M.; Fedoryak, O. D.; Moister, B. R.; Dore, T. M.  Bhc-diol as a Photolabile Protecting Group for Aldehydes and Ketones.  Org. Lett. 2003, 5, 2119-2122.
PMID: 12790543

Fedoryak, O. D.; Dore, T. M. Brominated Hydroxyquinoline as a Photolabile Protecting Group with Sensitivity to Multiphoton Excitation.  Org. Lett. 2002, 4, 3419-3422.
PMID: 12790543

Furuta, T.; Wang, S. S.-H.; Dantzker, J. L.; Dore, T. M.; Bybee, W. J.; Callaway, E. M.; Denk, W.; Tsien, R. Y.  Brominated 7-Hydroxycoumarin-4-ylmethyls: Novel Photolabile Protecting Groups with Biologically Useful Cross-sections for Two Photon Photolysis.  Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 1193-1200.
PMID: 9990000
PMCID: PMC15439

Wender, P. A.; Dore, T. M.  A Formal Synthesis of Crinipellin B Based on the Arene-Alkene meta-Photocycloaddition Reaction.  Tetrahedron Lett. 1998, 39, 8589-8592.

Wender, P. A.; Dore, T. M.; deLong, M. A.  An Arene-Alkene Photocycloaddition-Radical Cyclization Cascade: The First Syntheses of cis,cis,cis,trans-[5.5.5.5]-Fenestranes.  Tetrahedron Lett. 1996, 37, 7687-7690.

Jesus, A. R.; Harrison, B. A.; Dore, T. M. Sodium Glucose Co-Transporter Inhibitors for the Treatment of Diabetes. In Burger's Medicinal Chemistry, Drug Discovery and Development; 8^th ed.; Abraham, D. J., ; Myers, M., Eds.; Wiley: Hoboken, NJ, 2021, Vol. 4, Chapter 3. Invited contribution.

Hampton, S. E.; Dore, T. M.; Schmidt, W. K. Rce1: Mechanism and Inhibition. Crit. Rev. Biochem. Mol. Biol. 2018, 53, 157-174.
PMID: 29424242
PMCID: PMC5874806

Dore, T. M.; Schmidt, W. K. Isoprenylated Protein Peptidase Rce1p. In Handbook of Proteolytic Enzymes; 3rd ed.; Rawlings, N. D., Salvesen, G. S., Eds.; Elsevier: Oxford, UK, 2013, Vol. 2, p 1720-1726.

Schmidt, W. K.; Dore, T. M. The Ras Converting Enzyme (Rce1p):  Orthologs, Enzymology, and Inhibitors. In The Enzymes; Tamanoi, F., Hrycyna, C., Bergo, M., Eds.; Elsevier/Academic Press: New York, 2011; Vol. 30B, p 231-258.

Dore, T. M.; Wilson, H. C. Chromophores for the Delivery of Bioactive Molecules with Two-Photon Excitation. In Photosensitive Molecules for Controlling Biological Function; Chambers, J. J., Kramer, R. H., Eds.; Humana Press: New York, 2011, p 57-92.

Dore, T. M.  Multiphoton Phototriggers for Exploring Cell Physiology.  In Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules; Goeldner, M.; Givens, R. S., Eds.; Wiley-VCH: Weinheim, Germany, 2005; p 435-459.

Golde, C. M; Dore, T. M.  The Survey of Doctoral Education and Career Preparation: The Importance of Disciplinary Contexts.  In Paths to the Professoriate: Strategies for Enriching the Preparation of Future Faculty; Wulff, D. H.; Austin, A. E., Eds.; Jossey-Bass: San Francisco, 2004; p 19-45.

Golde, C. M.; Dore, T. M. At Cross Purposes: What the Experiences of Today's Doctoral Students Reveal About Doctoral Education; The Pew Charitable Trusts: Philadelphia, PA, January 2001. http://www.phd-survey.org.

Wender, P. A.; Dore, T. M.  Intra- and Intermolecular Cycloadditions of Benzene Derivatives.  In Handbook of Organic Photochemistry and Photobiology; Horspool, W. M.; Song, P.-S., Eds.; CRC Press, Inc.: Boca Raton, FL, 1995; p 280-290.

Wender, P. A.; Howbert, J. J.; Dore, T. M.  The Total Synthesis of (±)-alpha-Cedrene.  In Photochemical Key Steps in Organic Synthesis; Mattay, J.; Griesbeck, A. G., Eds.; VCH Verlagsgesellschaft: Weinheim, Germany, 1994; p 181-185.

Dore, T. M.; Lauderdale, J. D.; Rea, A. C.; Muliawan, A. P.; McLean D. M. BHQ-Conjugates, and Related Compounds, Methods of Making the Same, and Methods of Use Thereof. Patent Application PCT/US12/44567, June 28, 2012.  Amended from provisional U.S. patent applications 61511586 of July 26, 2011 and 61501967 of June 28, 2011.

Dore, T. M.; Zhu, Y.; Reddie, K. G., Lauderdale, J. D. BHQ-Gated Nucleotide Probes Photolysable by Two-Photon Excitation. U.S. Patent 8,173,620, May 8, 2012.  U.S. Patent Application 12544523, August 20, 2009.  Amended from provisional patent application of August 20, 2008.

Dore, T. M. Light-Activated Chemotaxis. Cell Chem. Biol. 2016, 23, 531-532.
PMID: 27203370

Dore, T. M. Preview: Correlating Enzyme Activity and Cellular Behavior.  Chem. Biol. 2007, 14, 1202-1203.
PMID: 18022557

Wender, P. A.; Dore, T. M. Commentary on Radical Carboxylation: Ester Synthesis from Alkyl Iodides, Carbon Monoxide, and Alcohols under Irradiation Conditions.  Chemtracts 1998, 11, 268-273.