Affiliation: NYU Abu Dhabi
Education: BSc (Honours), Chemistry with Molecular Medicine, University of Hull; MSc Chemistry by Research, University of Manchester
Shaneela is a Ph.D. student at New York University and is associated with NYU Abu Dhabi as a Global Ph.D. Student Fellow. Before joining NYU, she obtained an M.Sc. in Chemistry by Research in 2015 from Manchester University, Manchester, United Kingdom, and a BSc in Chemistry with Molecular Medicine in 2014 from the University of Hull, Hull, United Kingdom. Shaneela’s research interests lie at the interface of chemistry and biology. She joined the Dore Laboratory in 2018. Her current research is aimed at synthesizing inhibitors of Ras Converting Enzyme (Rce1), which catalyzes an important reaction in the processing of the oncogene Ras.
Ras protein family members are monomeric low molecular weight GTP-binding proteins that are involved in cell differentiation, proliferation, survival, and carcinogenesis. Activating Ras mutations are common in cancer. Ras Converting Enzyme (Rce1) is an important enzyme in the canonical post-translational modification of Ras. The aim of the research is to discover small molecule inhibitors with high potency against Rce1 that can provide information on the proteolytic mechanism and enable the investigation of the physiological role of Rce1 in regulating Ras and its potential as a therapeutic target in oncology.