Affiliation: NYU Abu Dhabi
Education: BSc, Pune University; MSc, Fergusson College; PhD, Indian Institute of Technology Madras (IITM)
Sangram Gore received a B.Sc. in chemistry in 2002 from Pune University and an M.Sc. in organic chemistry in 2004 from Fergusson College, Pune, India. He obtained a Ph.D. degree in 2012 from the Indian Institute of Technology Madras, India with Prof. S. Baskaran; his dissertation was entitled “Development of New Synthetic Methods in Low Melting Mixtures and Asymmetric Organocatalytic Aldol Reaction”. During his graduate studies, was an INDIGO exchange student with Prof. Burkhard Koenig, at University of Regensburg, Germany, where he worked on the design and development of novel low melting mixtures as green solvents for the synthesis of important substructures present in biologically active natural products. He also worked as a research internship student at BASF, Ludwigshafen, Germany. From 2013 to 2015, he moved to Nagoya University, Japan for postdoctoral studies with Prof. Masato Kitamura, working on multistep synthesis of chiral Lewis acid-Bronsted base bifunctional catalysts and their application to enantioselective transformations. Sangram joined the Dore laboratory in 2015 as a postdoctoral associate. He works on photoactivation by 1- and 2-photon excitation of TRPV1 channels using caged vanilloids.
In the peripheral nervous system, nociceptive sensory neurons (nociceptors) detect noxious stimuli and convert these stimuli into action potentials that are transmitted to the central nervous system. The vast majority of nociceptive neurons express the vanilloid receptor, TRPV1, a ligand-gated cation channel with high permeability to Ca2+ ions. Novel photoactivatable vanilloids developed from our laboratory will activate TRPV1 channels through 1- and 2-photon excitation. The vanilloid photorelease would be a powerful method for probing peripheral nerve terminals of TRPV1-expressing nociceptive neurons in densely innervated tissue with high temporal and spatial precision.