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Postdoctoral Associate Affiliation: NYU Abu Dhabi
Education: MS, Medicinal Chemistry, PhD, Pharmaceutical Sciences, University of Siena
Davide Deodato obtained an M.S. (with Honor) in medicinal chemistry from the University of Siena in Italy with a thesis regarding the design and synthesis of benzofurazan derivatives with anti-influenza properties. He then received a Ph.D. in pharmaceutical sciences from the same institution in 2016 under the supervision of Prof. Maurizio Botta. During his graduate studies, Davide was involved in several drug discovery projects targeting infectious disease: bacterial and fungal infections, influenza, and tuberculosis. He joined the Dore Laboratory in 2016, where he is currently working on photoactivatable morpholino oligomers.
Morpholino-based antisense oligonucleotides (MOs) represent powerful reagents to control and study gene function in developing organisms, especially zebrafish. Nevertheless, their utility has been hindered by the lack of temporal and spatial control over gene knockdown. This regulation can be achieved by preparing light-activated MOs suitable for use in living zebrafish embryos. These novel reagents will enable the study of gene function with spatiotemporal control, providing new important insights into embryonic development.