Adna P. Muliawan

Adna P. Muliawan

Graduate Student Affiliation: NYU Abu Dhabi
Email: apm404@nyu.edu
Education: BA, Emory University


One way of achieving spatiotemporal release of a biologically active molecule is by attaching a photoremovable protecting group (PPG) - a moiety that deactivates the molecule when attached (“caged” form), but can subsequently release the active species by cleavage with light (“uncaging”), especially 2-photon excitation (2PE) using near-infrared light. Design of efficient PPGs with sensitivity to 2PE requires an understanding of the photochemical and photophysical processes involved in releasing the biological effector. Using a variety of techniques, the mechanism of photolysis of quinoline-based PPGs is under investigation.

Research

One way of achieving spatiotemporal release of a biologically active molecule is by attaching a photoremovable protecting group (PPG) - a moiety that deactivates the molecule when attached (“caged” form), but can subsequently release the active species by cleavage with light (“uncaging”), especially 2-photon excitation (2PE) using near-infrared light. Design of efficient PPGs with sensitivity to 2PE requires an understanding of the photochemical and photophysical processes involved in releasing the biological effector. Using a variety of techniques, the mechanism of photolysis of quinoline-based PPGs is under investigation.