tim-dore-FG0I8482
Timothy Dore, Associate Professor of Chemistry, Science NYUAD

Timothy Dore

Associate Professor of Chemistry, Science

Affiliation: NYU Abu Dhabi

Biography

Timothy Dore’s scientific interests lie at the interface of chemistry and biology, creating new technology to study complex biological systems, especially the brain. After graduate work in synthetic organic chemistry in Paul Wender's laboratory, he completed postdoctoral training in Roger Tsien's laboratory at the Howard Hughes Medical Institute and the University of California, San Diego. He was a faculty member at the University of Georgia in the United States prior to joining NYUAD in 2012.

Selected Publications

  • Jesus, A. R.; Vila-Viçosa, D.; Machuqueiro, M.; Marques, A. P.; Dore, T. M.; Rauter, A. P. Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation. J. Med. Chem. 2017, 60. 568-579.
    PMID: 28098449
    http://dx.doi.org/10.1021/acs.jmedchem.6b01134
  • Mohammed, I.; Hampton, S. E.; Ashall, L.; Hildebrandt, E. R.; Kutlik, R. A.; Manandhar, S. P.; Floyd, B. J.; Smith, H. E.; Dozier, J. K.; Distefano, M. D.; Schmidt, W. K.; Dore, T. M. 8-Hydroxyquinoline-Based Inhibitors of the Rce1 Protease Disrupt Ras Membrane Localization in Human Cells. Bioorg. Med. Chem. 2016, 24, 160-178.
    PMID: 26706114
    PMCID: PMC4749511
    http://dx.doi.org/10.1016/j.bmc.2015.11.043
  • McLain, D. E.; Rea, A. C.; Widegren, M. B.; Dore, T. M. Photoactivatable, biologically-relevant phenols with sensitivity toward 2-photon excitation. Photochem. Photobiol. Sci. 2015, 14, 2141-2158.
    PMID: 26467796
    PMCID: PMC4661061
    http://dx.doi.org/10.1039/C5PP00334B
  • Rea, A. C.; Vandenberg, L. N.; Ball, R. E.; Snouffer, A. A.; Hudson, A.; Zhu, Y.; McLain, D. E.; Johnston, L. L.; Lauderdale, J. D.; Levin, M.; Dore, T. M. Light Activated Serotonin for Exploring Its Action in Biological Systems. Chem. Biol. 201320, 1536-1546.
    http://dx.doi.org/10.1016/j.chembiol.2013.11.005
  • Ma, J.; Rea, A. C.; An, H.; Ma, C.; Guan, X.; Li, M.-D.; Su, T.; Yeung, C. S.; Harris, K. T.; Zhu, Y.; Nganga, J. L.; Fedoryak, O. D.; Dore, T. M.; Phillips, D. L. Unraveling the Mechanism of the Photodeprotection Reaction of 8-Bromo- and 8-Chloro-7-hydroxyquinoline Caged Acetates. Chem.—Eur. J. 2012, 18, 6854-6865. 
    PMID: 22511356
    PMCID: PMC3531613
    http://dx.doi.org/10.1002/chem.201200366

Patents and Patent Applications

  • Dore, T. M.; Lauderdale, J. D.; Rea, A. C.; Muliawan, A. P.; McLean D. M. BHQ-Conjugates, and Related Compounds, Methods of Making the Same, and Methods of Use Thereof. Patent Application PCT/US12/44567, June 28, 2012.  Amended from provisional U.S. patent applications 61511586 of July 26, 2011 and 61501967 of June 28, 2011.
  • Dore, T. M.; Zhu, Y.; Reddie, K. G., Lauderdale, J. D. BHQ-Gated Nucleotide Probes Photolysable by Two-Photon Excitation. U.S. Patent 8,173,620, May 8, 2012.  U.S. Patent Application 12544523, August 20, 2009.  Amended from provisional patent application of August 20, 2008.